DefenCath® (taurolidine and heparin) catheter lock solution is indicated to reduce the incidence of catheter-related bloodstream infections (CRBSI) in adult patients with kidney failure receiving chronic hemodialysis (HD) through a central venous catheter (CVC). This drug is indicated for use in a limited and specific population of patients.


Berkeley Heights, NJ – April 11, 2024 – CorMedix Inc. (Nasdaq: CRMD), a biopharmaceutical company focused on developing therapeutic products for life-threatening diseases and conditions, today announced that two abstracts have been accepted for presentation at the Society for Healthcare Epidemiology of America (SHEA) conference being held in Houston, Texas, April 16 – 19, 2024. 

The first abstract being presented examines in vitro antimicrobial activity of taurolidine against a set of recent clinical isolates representative of bacteria recovered from the LOCK-IT 100 trial and those commonly associated with CRBSI. Based on these data, taurolidine demonstrated broad antimicrobial activity against all gram-positive bacteria, including non-tuberculosis Mycobacteria (NTM), gram-negative bacteria, and fungal isolates tested.  In addition, the activity of taurolidine was unaffected by resistance to common antibiotics.  

A second abstract being presented highlights a retrospective analysis that was conducted to characterize demographics, outcomes and economics associated with the development of hospital acquired bloodstream infections (HA-BSI) in patients receiving hemodialysis through a CVC while in an inpatient setting.  During the study period, all-cause mortality for patients with HA-BSI was 27.8% and median length of stay was 25 days compared to 6 days for HD-CVC patients without a BSI.

The abstract details are included below. 

SHEA Conference Abstracts 

Title: In Vitro Antimicrobial Activity of Taurolidine against Isolates Commonly Associated with Catheter-Related Bloodstream Infections 

Timing: Thursday, April 18, 12:00 – 1:30pm CDT

Title: Impacts of Hospital Acquired Bloodstream Infections in Patients Undergoing Hemodialysis Through a Central Venous Catheter 

Timing: Friday, April 19, 12:00 – 1:30pm CDT

About CorMedix  

CorMedix Inc. is a biopharmaceutical company focused on developing and commercializing therapeutic products for the prevention and treatment of life-threatening conditions and diseases. The Company is focused on commercializing its lead product DefenCath®, which was approved by the FDA on November 15, 2023. CorMedix anticipates the commercial launch of DefenCath in inpatient settings in April 2024 and in outpatient settings in July 2024, pending a timely implementation of TDAPA. CorMedix also intends to develop DefenCath as a catheter lock solution for use in other patient populations.  For more information visit: 

Forward-Looking Statements 

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Investor Contact:
Dan Ferry
Managing Director
LifeSci Advisors 
(617) 430-7576