DefenCath® (taurolidine and heparin) catheter lock solution is indicated to reduce the incidence of catheter-related bloodstream infections (CRBSI) in adult patients with kidney failure receiving chronic hemodialysis (HD) through a central venous catheter (CVC). This drug is indicated for use in a limited and specific population of patients.

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Publications and Presentations

  • Nov. 01, 2023

    Taurolidine/Heparin Lock Solution and Catheter-Related Bloodstream Infection in Hemodialysis: A Randomized, Double-Blind, Active-Control, Phase 3 Study

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  • Oct. 20, 2021

    Incremental Cost of Catheter related Bloodstream Infections among Central Venous Catheter Dependent Hemodialysis Patients: A Claims Based Assessment of USRDS Linked Medicare Data

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  • Nov. 4 – Nov. 7, 2021

    Hospitalization Risk and Long-term Complications Associated with Catheter Related Bloodstream Infections Among Hemodialysis Patients

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  • Nov. 4 – Nov. 7, 2021

    Catheter Related Bloodstream Infections Incidence and Associated Mortality Risk: Analysis of Merged United States Renal Data System Medicare Claims

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  • May 10, 2019

    LOCK-IT 100 NKF Presentation As Presented May 10 2019

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  • December 6, 2017

    Postmarketing experience with Neutrolin® (taurolidine, heparin, calcium citrate) catheter lock solution in hemodialysis patients

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  • 2014

    Möglichkeiten zur Verringerung von Bakteriämierisiken bei Verwendung von getunnelten zentralvenösen Dialysekathetern

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  • July 2014

    Tunneled Catheters with Taurolidine-Citrate-Heparin Lock Solution Significantly Improve the Inflammatory Profile of Hemodialysis Patients

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  • 2002

    Prevention of Hemodialysis Catheter-Related Bloodstream Infection Using an Antimicrobial Lock

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  • 2013

    Central Venous Catheters and Catheter Locks in Children With Cancer: A Prospective Randomized Trial of Taurolidine Versus Heparin

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  • April 14, 2009

    Taurolidine lock is highly effective in preventing catheter-related bloodstream infections on patients on home parenteral nutrition: A heparin-controlled prospective trial

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